I have systemic mycoplasma hominis (an opportunistic infection gotten by persons with serious immune system disease). This parasite is anti-plasmin and pro-fibrin, resulting in a mild variant sepsis, and fibrin deposition throughout the circulatory system on vessel walls. Nattokinase (bacillus natto-fermented soybeans derived enzyme that lyses fibrin) is now available in pills. Natto food itself, from which nattokinase is derived, also increases serum levels of nattokinase. I began eating natto and taking nattokinase pills to potentiate the antibiotic (moxifloxacin--a fluoroquinolone) I take chronically against the mycoplasma. It most definitely does this, and my myco titer has dropped significantly. But my vein walls have become much more elastic and permeable--I am on the immune modulator Ampligen administered twice weekly IV. my veins are excellent--but now each stick results in an infiltration or extravasation event. Question: has anyone any info on natto or other similar enzymes such as streptokinase or urokinase or Genentech's Activase (Actilyse) or TNK-ase and extravasation? Can anyone advise on how to optimize fibrinolysis and IV drug tolerance? thanks--Hugo

By rbry2423 on Saturday, July 31, 2004 - 02:37 am:

you need to control your INR at a rate that allows sufficient clotting.. ask your doctor about inr monitoring for warfarin therapy

maybe the natto combined with other drugs is not allowing fibrin to exert its temporary glue action sufficiently